Samson draft control11/11/2022 ![]() ![]() ![]() The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.ĭespite great achievements by insecticide-treated nets (ITNs) and indoor residual spraying (IRS) in reducing malaria transmission, modeling and empirical evidence demonstrate that these tools are insufficient to eliminate malaria transmission in many settings today, even when combined with treatment with antimalarial drugs such as artemisinin combination therapies. This work was supported by the University of California, San Francisco, Group Health Group Malaria Elimination Initiative through funding from The Parker Foundation. HS and JM acknowledges financial support from UC-MEXUS grant. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: SSK acknowledges financial support from a Wellcome Trust Training Fellowship grant # 107599/Z/15/Z. Received: Accepted: OctoPublished: December 1, 2017Ĭopyright: © 2017 Kiware et al. Oliveira, Universidade Federal do Rio de Janeiro, BRAZIL (2017) Attacking the mosquito on multiple fronts: Insights from the Vector Control Optimization Model (VCOM) for malaria elimination. larviciding at 80% coverage, endectocide treated cattle at 50% coverage and attractive toxic sugar baits at 50% coverage) may be sufficient to suppress all the three species to an extent required to achieve local malaria elimination.Ĭitation: Kiware SS, Chitnis N, Tatarsky A, Wu S, Castellanos HMS, Gosling R, et al. arabiensis) and adding interventions that do not require human participation (e.g. Sample model simulations indicate that, starting with ITNs at a coverage of 50% ( An. The model was used to sweep through parameters space to select the best optimal intervention packages. ![]() In all settings, we considered baseline ITN coverage of 50% or 80% in addition to a range of other vector control tools to interrupt malaria transmission. We considered areas having low, moderate and high malaria transmission, corresponding to entomological inoculation rates of 10, 50 and 100 infective bites per person per year, respectively. The model simulations were performed for the main three malaria vectors in sub-Saharan Africa, Anopheles gambiae s. We have developed a model of mosquito population dynamic to describe the mosquito life and feeding cycles and to optimize the impact of vector control intervention combinations at suppressing mosquito populations. ![]()
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